EDEM2

Across TCGA cell cohorts, EDEM2 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EDEM2-associated genes across cancer lineages are PYDC2, REG3G, and SMR3A. Each is linked with EDEM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM2-to-partner and partner-to-EDEM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC2 grouped by EDEM2-low versus EDEM2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM2→partner) and Y-score (partner→EDEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PYDC2 →	+0.203	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
LUNG_SCLC	SMR3A →	+0.193	+5.643	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.061	+3.023	<.001	.002	3	1
LARGE_INTESTINE	CMKLR1 →	+0.102	+3.830	.008	.003	3	1
LARGE_INTESTINE	C12orf40 →	+0.005	+2.777	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PYDC2 by EDEM2 expression — LUNG_SCLC

Explore this box plot interactively →