EDEM1

Across TCGA pan-cancer cohorts, EDEM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EDEM1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EDEM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EDEM1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where EDEM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.399	0.872	.001	21	view →
PDAC	DFS	Tertile	II,III,IV	0.490	0.225	.039	3	view →
UCEC	DFS	Median	All	1.000	0.731	.026	2	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.635	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EDEM1–LSCC (OS)

Open the LSCC breakdown →