EDEM1

Across TCGA patient cohorts, EDEM1 mutation is significantly associated with the RNA expression of many other genes, with 2,196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDEM1-associated genes across cancer lineages are RNU7-174P, RN7SKP132, and RNU4-45P. Each is linked with EDEM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EDEM1-to-partner and partner-to-EDEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-174P grouped by EDEM1-low versus EDEM1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM1→partner) and Y-score (partner→EDEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-174P →	+0.573	+5.505	<.001	.004	3	3
UCEC	RN7SKP132 →	+0.075	+3.140	<.001	.004	3	3
LUSC	RNU4-45P →	+0.174	+4.906	<.001	.003	3	3
STAD	MIR4662B →	+0.694	+3.782	<.001	.007	3	3
SKCM	MED28P2 →	+0.060	+4.897	<.001	.002	3	3
UCEC	C16orf87 →	+0.518	+1.890	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,196 associations by consensus.

RNU7-174P by EDEM1 expression — HNSC

Explore this box plot interactively →