EDEM1

Across TCGA patient cohorts, EDEM1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDEM1-associated genes across cancer lineages are A-Raf_pS299, eEF2, and eIF4E. Each is linked with EDEM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EDEM1-to-partner and partner-to-EDEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by EDEM1-low versus EDEM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM1→partner) and Y-score (partner→EDEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.137	-3.700	.002	.001	3	3
UCEC	eEF2 →	+0.294	+3.169	.028	.018	3	2
UCEC	eIF4E →	+0.188	+2.700	.017	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-2.700	.001	.006	3	2
UCEC	MEK1 →	+0.335	+2.115	.014	.017	3	2
UCEC	p21 →	+0.157	+3.700	.029	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

A-Raf_pS299 by EDEM1 expression — UCEC

Explore this box plot interactively →