EDEM1

Across TCGA cell cohorts, EDEM1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EDEM1-associated genes across cancer lineages are TNRC6B, USP14, and SLC5A5. Each is linked with EDEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM1-to-partner and partner-to-EDEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6B grouped by EDEM1-low versus EDEM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM1→partner) and Y-score (partner→EDEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+1.042	+3.064	<.001	.009	3	1
LARGE_INTESTINE	USP14 →	+0.647	+3.067	.009	.009	3	1
LARGE_INTESTINE	SLC5A5 →	+0.325	+2.938	<.001	.003	3	1
LARGE_INTESTINE	PITX3 →	+0.166	+3.906	<.001	.001	3	1
LARGE_INTESTINE	TMEM33 →	+0.766	+3.064	<.001	.009	3	1
LARGE_INTESTINE	KCNK17 →	+0.061	+2.906	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

TNRC6B by EDEM1 expression — LARGE_INTESTINE

Explore this box plot interactively →