EDDM3B

Across TCGA patient cohorts, EDDM3B mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDDM3B-associated genes across cancer lineages are PPP1R1C, PRSS53, and MAT1A. Each is linked with EDDM3B in more than 1 cancer types. Because this analysis shows association rather than direction, both EDDM3B-to-partner and partner-to-EDDM3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R1C grouped by EDDM3B-low versus EDDM3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDDM3B→partner) and Y-score (partner→EDDM3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R1C →	+0.640	+3.502	<.001	.002	3	1
UCEC	PRSS53 →	+0.487	+3.534	<.001	.002	3	1
UCEC	MAT1A →	-1.203	-3.459	.001	.005	3	1
UCEC	VPS26B →	+0.492	+3.201	.005	.009	3	1
UCEC	NCAPD3 →	+0.935	+3.470	<.001	.003	3	1
UCEC	GPATCH11 →	+0.564	+3.470	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

PPP1R1C by EDDM3B expression — UCEC

Explore this box plot interactively →