EDDM3B

Across TCGA patient cohorts, EDDM3B mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDDM3B-associated genes across cancer lineages are EGFR_pY1068, Chk2, and INPP4B. Each is linked with EDDM3B in more than 1 cancer types. Because this analysis shows association rather than direction, both EDDM3B-to-partner and partner-to-EDDM3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EDDM3B-low versus EDDM3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDDM3B→partner) and Y-score (partner→EDDM3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.281	-3.321	.032	.010	3	1
UCEC	Chk2 →	-0.250	-3.000	.041	.036	3	1
UCEC	INPP4B →	-0.424	-3.000	.012	.036	2	1
UCEC	MEK1 →	+0.547	+3.169	.004	.019	2	1
UCEC	c-Jun_pS73 →	-0.227	-3.321	.006	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1068 by EDDM3B expression — UCEC

Explore this box plot interactively →