EDDM3A

Across TCGA pan-cancer cohorts, EDDM3A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EDDM3A data layer compared with 15 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EDDM3A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated EDDM3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, ESCA, and LIHC are the cancer types where EDDM3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.439	.017	28	view →
ESCA	DFS	Median	II,III,IV	0.162	0.525	.011	18	view →
LIHC	OS	Median	All	0.098	0.777	<.001	12	view →
SKCM	OS	Median	All	0.405	0.783	.026	6	view →
GBM	DFS	Median	All	1.000	0.192	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EDDM3A–UCEC (DFS)

Open the UCEC breakdown →