Across TCGA patient cohorts, EDARADD protein abundance is significantly associated with the RNA expression of many other genes, with 3,294 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EDARADD-associated genes across cancer lineages are SIGLEC6, TUBAP8, and OTX1. Each is linked with EDARADD in more than 2 cancer types. Because this analysis shows association rather than direction, both EDARADD-to-partner and partner-to-EDARADD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDARADD→partner) and Y-score (partner→EDARADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIGLEC6 →	-0.671	-0.974	.002	<.001	3	3
BRCA	TUBAP8 →	+1.193	+0.829	<.001	<.001	3	2
HNSC	OTX1 →	+0.854	+0.388	.009	.003	3	2
LSCC	PLXDC2 →	-0.747	-0.664	<.001	.001	3	2
LUAD	NCAPH →	+0.936	+1.062	<.001	<.001	3	2
HNSC	PRICKLE1 →	-0.736	-0.419	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,294 associations by consensus.

Exploration

EDARADD survival (RNA) · tumor vs normal (RNA) · all EDARADD data types