ECT2

Across TCGA patient cohorts, ECT2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECT2-associated genes across cancer lineages are ATM, Ku80, and PDCD4. Each is linked with ECT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ECT2-to-partner and partner-to-ECT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ECT2-low versus ECT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECT2→partner) and Y-score (partner→ECT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.441	-1.584	.006	.019	3	5
UCEC	Ku80 →	+0.214	+1.939	.011	.003	3	2
UCEC	PDCD4 →	-0.389	-1.896	.021	.015	3	2
UCEC	Caspase-8 →	-0.273	-3.973	.002	<.001	3	2
UCEC	4E-BP1 →	+0.262	+3.321	.007	.009	3	2
UCEC	C-Raf →	+0.165	+1.584	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by ECT2 expression — UCEC

Explore this box plot interactively →