ECT2

Across TCGA cell cohorts, ECT2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECT2-associated genes across cancer lineages are KCNA4, H2BW1, and DEFB126. Each is linked with ECT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECT2-to-partner and partner-to-ECT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA4 grouped by ECT2-low versus ECT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECT2→partner) and Y-score (partner→ECT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	H2BW1 →	+0.269	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	DEFB126 →	+0.480	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	LYZL2 →	+0.310	+4.803	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SNTG2 →	+0.553	+3.879	.003	.003	3	1
LUNG_NSCLC_LUAD	USP17L19 →	+0.003	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KCNA4 by ECT2 expression — BLOOD_Leukemia

Explore this box plot interactively →