ECSIT

Across TCGA patient cohorts, ECSIT mutation is significantly associated with the RNA expression of many other genes, with 502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECSIT-associated genes across cancer lineages are CNN2P10, MIR8070, and LINC01202. Each is linked with ECSIT in more than 1 cancer types. Because this analysis shows association rather than direction, both ECSIT-to-partner and partner-to-ECSIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNN2P10 grouped by ECSIT-low versus ECSIT-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECSIT→partner) and Y-score (partner→ECSIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	CNN2P10 →	+0.096	+5.355	<.001	.005	3	2
CESC	MIR8070 →	+0.548	+4.688	<.001	.001	3	2
CESC	LINC01202 →	+0.305	+5.124	<.001	<.001	3	2
SKCM	H2AC1 →	+0.080	+4.665	<.001	<.001	3	2
SKCM	BLOC1S2P1 →	+0.092	+3.402	.001	.007	3	2
SKCM	FAM138A →	+0.016	+4.897	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 502 associations by consensus.

CNN2P10 by ECSIT expression — LIHC

Explore this box plot interactively →