ECSIT

Across TCGA patient cohorts, ECSIT mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECSIT-associated genes across cancer lineages are GMP, MPP, and Macrophages. Each is linked with ECSIT in more than 2 cancer types. Because this analysis shows association rather than direction, both ECSIT-to-partner and partner-to-ECSIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by ECSIT-low versus ECSIT-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECSIT→partner) and Y-score (partner→ECSIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GMP →	+0.054	+2.853	.023	.037	3	3
CESC	MPP →	+0.020	+2.924	.044	.033	3	2
UCEC	Macrophages →	+0.016	+2.761	.023	.001	3	1
UCEC	Macrophages M1 →	+0.021	+3.551	.004	.005	3	1
UCEC	aDC →	+0.081	+2.332	.029	.020	1	1
UCEC	Class-switched memory B-cells →	-0.061	-2.321	.032	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GMP by ECSIT expression — CESC

Explore this box plot interactively →