ECSIT

Across TCGA cell cohorts, ECSIT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,586 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ECSIT-associated GO terms across cancer lineages are NADH dehydrogenase complex assembly, Mitochondrial respiratory chain complex I assembly, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with ECSIT in more than 14 cancer types. Because this analysis shows association rather than direction, both ECSIT-to-partner and partner-to-ECSIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NADH dehydrogenase complex assembly grouped by ECSIT-low versus ECSIT-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ECSIT→partner) and Y-score (partner→ECSIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NADH dehydrogenase complex assembly →	+0.125	+0.914	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitochondrial respiratory chain complex I assembly →	+0.125	+0.914	<.001	<.001	3	15
URINARY_TRACT	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.080	+1.063	.007	<.001	3	13
URINARY_TRACT	Electron transport coupled proton transport →	+0.080	+1.063	.007	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Inner mitochondrial membrane organization →	+0.081	+0.810	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.194	+1.210	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,586 associations by consensus.

NADH dehydrogenase complex assembly by ECSIT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →