ECSIT

Across TCGA cell cohorts, ECSIT mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECSIT-associated genes across cancer lineages are HRG, TMEM244, and PNLIPRP3. Each is linked with ECSIT in more than 1 cancer types. Because this analysis shows association rather than direction, both ECSIT-to-partner and partner-to-ECSIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRG grouped by ECSIT-low versus ECSIT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECSIT→partner) and Y-score (partner→ECSIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HRG →	+0.402	+3.855	<.001	.007	3	1
BLOOD_Leukemia	TMEM244 →	+0.271	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.008	+3.551	.007	.009	3	1
BLOOD_Leukemia	CFHR2 →	+0.245	+5.124	<.001	<.001	3	1
LARGE_INTESTINE	RASGEF1C →	+0.245	+3.333	.001	.009	3	1
LARGE_INTESTINE	SLC25A31 →	+0.062	+3.115	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

HRG by ECSIT expression — BLOOD_Leukemia

Explore this box plot interactively →