ECSCR

Across TCGA pan-cancer cohorts, ECSCR RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ECSCR data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ECSCR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ECSCR expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

UVM, KIRP, and KIRC are the cancer types where ECSCR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.407	0.763	<.001	124	view →
KIRP	OS	Tertile	All	0.420	0.885	<.001	88	view →
KIRC	OS	Tertile	All	0.728	0.528	<.001	85	view →
MESO	OS	Median	All	0.285	0.484	.001	55	view →
THCA	DFS	Tertile	IV	0.938	0.489	<.001	54	view →
LGG	OS	Tertile	All	0.739	0.881	<.001	39	view →
LUSC	DFS	Quartile	All	0.307	0.519	.004	24	view →
SCLC	OS	Median	II,III,IV	0.492	0.978	.021	21	view →
HNSC	OS	Quartile	III,IV	0.484	0.818	.001	14	view →
LAML	DFS	Median	All	0.646	0.486	.009	14	view →
BLCA	DFS	Median	IV	0.103	0.312	.007	11	view →
DLBC	DFS	Median	All	0.922	0.717	.033	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ECSCR–UVM (OS)

Open the UVM breakdown →