ECRG4

Across TCGA patient cohorts, ECRG4 mutation is significantly associated with the RNA expression of many other genes, with 1,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECRG4-associated genes across cancer lineages are DFFA, RPP14, and MELK. Each is linked with ECRG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECRG4-to-partner and partner-to-ECRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DFFA grouped by ECRG4-low versus ECRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECRG4→partner) and Y-score (partner→ECRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DFFA →	+0.482	+3.507	.001	.002	3	2
UCEC	RPP14 →	+0.435	+2.354	<.001	.003	3	2
UCEC	MELK →	+0.809	+2.332	.002	.003	3	2
UCEC	IDH3A →	+0.528	+2.354	.006	.003	3	2
UCEC	RFWD3 →	+0.571	+3.212	.002	.009	3	2
UCEC	RRM2 →	+0.912	+2.708	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,116 associations by consensus.

DFFA by ECRG4 expression — UCEC

Explore this box plot interactively →