ECM2

Across TCGA pan-cancer cohorts, ECM2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ECM2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ECM2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ECM2 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where ECM2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ECM2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+1.098	.001	7	view →
PDAC	Female	All	+0.995	<.001	6	view →
LSCC	Female	All	−0.452	<.001	4	view →
LUAD	All	All	−0.179	.002	4	view →
OV	All	All	−0.854	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ECM2–CCRCC

Open the CCRCC breakdown →