ECM2

Across TCGA cell cohorts, ECM2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECM2-associated genes across cancer lineages are SEMG2, IFNK, and TBC1D21. Each is linked with ECM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECM2-to-partner and partner-to-ECM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by ECM2-low versus ECM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECM2→partner) and Y-score (partner→ECM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.398	+2.878	.005	.009	3	1
LARGE_INTESTINE	IFNK →	+0.022	+3.242	.007	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ELOA3DP →	+0.030	+3.103	<.001	.004	3	1
LARGE_INTESTINE	PFN3 →	+0.105	+3.297	<.001	.002	3	1
LARGE_INTESTINE	LRRD1 →	+0.043	+4.125	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SEMG2 by ECM2 expression — LARGE_INTESTINE

Explore this box plot interactively →