ECM1

Across TCGA patient cohorts, ECM1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECM1-associated genes across cancer lineages are Annexin-1, ASNS, and ATM. Each is linked with ECM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECM1-to-partner and partner-to-ECM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ECM1-low versus ECM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECM1→partner) and Y-score (partner→ECM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.506	+2.070	.005	.001	3	2
UCEC	ASNS →	+0.423	+2.087	<.001	.005	3	2
UCEC	ATM →	-0.458	-2.070	.003	.001	3	2
UCEC	Cyclin-B1 →	+0.471	+2.459	.015	.018	3	2
UCEC	EGFR_pY1068 →	-0.198	-2.070	.022	.001	3	1
UCEC	EGFR →	-0.126	-2.295	.023	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Annexin-1 by ECM1 expression — UCEC

Explore this box plot interactively →