ECM1

Across TCGA cell cohorts, ECM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,661 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ECM1-associated GO terms across cancer lineages are Negative regulation of peptidase activity, Negative regulation of ossification, and Regulation of proteolysis. Each is linked with ECM1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ECM1-to-partner and partner-to-ECM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of peptidase activity grouped by ECM1-low versus ECM1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ECM1→partner) and Y-score (partner→ECM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of peptidase activity →	+0.370	+1.459	.005	<.001	3	13
STOMACH	Negative regulation of ossification →	+0.121	+2.909	<.001	<.001	3	13
BONE	Regulation of proteolysis →	+0.119	+2.416	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of biomineral tissue development →	+0.189	+3.495	<.001	<.001	3	12
BONE	Regulation of calcineurin-NFAT signaling cascade →	+0.166	+2.416	.001	<.001	3	12
LIVER	Actin filament depolymerization →	+0.166	+2.452	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,661 associations by consensus.

Negative regulation of peptidase activity by ECM1 expression — LUNG_SCLC

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