ECM1

Across TCGA cell cohorts, ECM1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECM1-associated genes across cancer lineages are OR8J2, ARL1, and EIF3M. Each is linked with ECM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECM1-to-partner and partner-to-ECM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8J2 grouped by ECM1-low versus ECM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECM1→partner) and Y-score (partner→ECM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR8J2 →	+0.052	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ARL1 →	+0.562	+3.064	.003	.009	3	1
LARGE_INTESTINE	EIF3M →	+0.562	+3.087	<.001	.006	3	1
LARGE_INTESTINE	GABRG1 →	+0.007	+2.518	.006	.006	3	1
LARGE_INTESTINE	SGSM1 →	+0.453	+3.302	.002	.008	3	1
LARGE_INTESTINE	CCT4 →	+0.669	+3.067	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR8J2 by ECM1 expression — SKIN

Explore this box plot interactively →