Across TCGA patient cohorts, ECI2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECI2-associated genes across cancer lineages are ATM, EGFR_pY1068, and MEK1. Each is linked with ECI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECI2-to-partner and partner-to-ECI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECI2→partner) and Y-score (partner→ECI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-3.308	.002	.009	3	2
UCEC	EGFR_pY1068 →	-0.311	-2.807	.004	.003	3	1
UCEC	MEK1 →	+0.355	+2.115	.026	.019	3	1
UCEC	Shc_pY317 →	-0.178	-2.115	.007	.019	3	1
UCEC	TIGAR →	+0.163	+1.611	.014	.043	3	1
UCEC	Caspase-7-cleavedD198 →	+0.708	+3.019	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

ECI2 survival (RNA) · tumor vs normal (RNA) · all ECI2 data types