ECHS1

Across TCGA patient cohorts, ECHS1 mutation is significantly associated with the RNA expression of many other genes, with 761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECHS1-associated genes across cancer lineages are RN7SL83P, RNU6-4P, and RPS24P1. Each is linked with ECHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECHS1-to-partner and partner-to-ECHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL83P grouped by ECHS1-low versus ECHS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHS1→partner) and Y-score (partner→ECHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL83P →	+0.499	+4.392	<.001	.006	3	2
UCEC	RNU6-4P →	+0.520	+2.765	<.001	<.001	3	2
UCEC	RPS24P1 →	+0.072	+2.658	.006	.005	3	2
UCEC	TRBV7-9 →	+0.894	+3.467	.001	.002	3	1
UCEC	MIR6781 →	+0.533	+1.874	.001	.008	3	1
UCEC	IGHV3-41 →	+0.753	+3.065	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 761 associations by consensus.

RN7SL83P by ECHS1 expression — COAD

Explore this box plot interactively →