ECHS1

Across TCGA patient cohorts, ECHS1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECHS1-associated genes across cancer lineages are mTOR_pS2448, eEF2, and EGFR_pY1068. Each is linked with ECHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECHS1-to-partner and partner-to-ECHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ECHS1-low versus ECHS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHS1→partner) and Y-score (partner→ECHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.146	-3.150	.030	.019	3	2
UCEC	eEF2 →	+0.456	+3.321	.004	.009	3	1
UCEC	EGFR_pY1068 →	-0.273	-2.000	.015	.032	3	1
UCEC	A-Raf_pS299 →	-0.191	-3.321	<.001	.010	3	1
UCEC	GSK-3_pS9 →	-0.418	-3.169	.021	.018	3	1
UCEC	IGFBP2 →	-0.806	-2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

mTOR_pS2448 by ECHS1 expression — UCEC

Explore this box plot interactively →