ECHS1

Across TCGA cell cohorts, ECHS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,914 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ECHS1-associated GO terms across cancer lineages are Pyrimidine deoxyribonucleotide biosynthetic process, DTMP biosynthetic process, and Positive regulation of mitochondrial RNA catabolic process. Each is linked with ECHS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ECHS1-to-partner and partner-to-ECHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyrimidine deoxyribonucleotide biosynthetic process grouped by ECHS1-low versus ECHS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHS1→partner) and Y-score (partner→ECHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Pyrimidine deoxyribonucleotide biosynthetic process →	+0.195	+0.819	.002	.009	3	10
UPPER_AERODIGESTIVE_TRACT	DTMP biosynthetic process →	+0.226	+1.048	.004	.001	3	9
LUNG_SCLC	Positive regulation of mitochondrial RNA catabolic process →	+0.126	+0.797	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Protein localization to microtubule →	+0.094	+0.921	.003	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.226	+1.048	.004	.001	3	9
LUNG_SCLC	Quinone metabolic process →	+0.089	+0.659	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,914 associations by consensus.

Pyrimidine deoxyribonucleotide biosynthetic process by ECHS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →