ECHS1

Across TCGA cell cohorts, ECHS1 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECHS1-associated genes across cancer lineages are AZD5582, Quizartinib, and WYE-125132. Each is linked with ECHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECHS1-to-partner and partner-to-ECHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5582 grouped by ECHS1-low versus ECHS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHS1→partner) and Y-score (partner→ECHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5582 →	+0.586	+2.646	.046	.047	3	1
LARGE_INTESTINE	Quizartinib →	+0.387	+2.652	.015	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.596	+2.652	.019	.045	3	1
LARGE_INTESTINE	CP466722 →	+0.431	+2.652	.029	.045	2	1
LARGE_INTESTINE	WZ3105 →	+0.828	+2.652	.016	.045	2	1
LARGE_INTESTINE	Y-39983 →	+0.534	+2.652	.012	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

AZD5582 by ECHS1 expression — LARGE_INTESTINE

Explore this box plot interactively →