ECHDC2

Across TCGA patient cohorts, ECHDC2 mutation is significantly associated with the RNA expression of many other genes, with 1,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECHDC2-associated genes across cancer lineages are RNU1-78P, RNA5SP295, and MIR128-1. Each is linked with ECHDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ECHDC2-to-partner and partner-to-ECHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-78P grouped by ECHDC2-low versus ECHDC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHDC2→partner) and Y-score (partner→ECHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-78P →	+0.361	+6.913	<.001	<.001	3	3
HNSC	RNA5SP295 →	+0.325	+5.015	<.001	.009	3	2
HNSC	MIR128-1 →	+0.385	+5.912	<.001	.002	3	2
CESC	RN7SL530P →	+0.311	+4.376	<.001	.002	3	2
UCEC	RNU6-1292P →	+0.213	+2.868	<.001	.009	3	2
UCEC	TRAJ10 →	+0.596	+2.216	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,250 associations by consensus.

RNU1-78P by ECHDC2 expression — SKCM

Explore this box plot interactively →