ECHDC2

Across TCGA patient cohorts, ECHDC2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECHDC2-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and MSH6. Each is linked with ECHDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECHDC2-to-partner and partner-to-ECHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ECHDC2-low versus ECHDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHDC2→partner) and Y-score (partner→ECHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.224	+2.000	.009	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-3.169	.007	.018	3	1
UCEC	MSH6 →	-0.531	-2.321	<.001	.033	3	1
UCEC	mTOR_pS2448 →	-0.166	-2.000	.013	.032	3	1
UCEC	mTOR →	-0.202	-2.700	.005	.006	3	1
UCEC	Notch1 →	+0.151	+3.179	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by ECHDC2 expression — UCEC

Explore this box plot interactively →