ECH1

Across TCGA pan-cancer cohorts, ECH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ECH1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ECH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ECH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where ECH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.314	0.705	.011	13	view →
HNSC	OS	Median	III,IV	0.809	0.572	.012	13	view →
PDAC	OS	Median	III,IV	0.737	0.441	.042	4	view →
CCRCC	OS	Quartile	II,III,IV	0.977	0.104	.036	3	view →
UCEC	DFS	Quartile	All	0.899	1.000	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ECH1–LUAD (DFS)

Open the LUAD breakdown →