ECH1

Across TCGA patient cohorts, ECH1 mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECH1-associated genes across cancer lineages are RNU6-1216P, ALDH7A1P2, and RNA5SP243. Each is linked with ECH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECH1-to-partner and partner-to-ECH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1216P grouped by ECH1-low versus ECH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECH1→partner) and Y-score (partner→ECH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1216P →	+0.239	+3.533	.005	.007	3	2
LIHC	ALDH7A1P2 →	+0.064	+6.305	<.001	.001	3	2
LUSC	RNA5SP243 →	+0.854	+4.048	.005	.005	3	2
UCEC	MIR4804 →	+0.311	+2.811	.005	.004	3	2
UCEC	RNU6-961P →	+0.104	+4.475	<.001	.003	3	2
UCEC	RN7SL354P →	+0.259	+2.374	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

RNU6-1216P by ECH1 expression — SKCM

Explore this box plot interactively →