ECH1

Across TCGA patient cohorts, ECH1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECH1-associated genes across cancer lineages are IGFBP2, Lck, and p27. Each is linked with ECH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECH1-to-partner and partner-to-ECH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by ECH1-low versus ECH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECH1→partner) and Y-score (partner→ECH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.655	-2.321	.044	.035	3	1
UCEC	Lck →	+0.263	+3.459	.009	.005	3	1
UCEC	p27 →	+0.239	+3.321	.029	.010	3	1
UCEC	Annexin-1 →	+0.534	+2.827	.043	.035	3	1
UCEC	ATM →	-0.494	-2.321	.030	.035	3	1
UCEC	ERK2 →	+0.215	+2.321	.026	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IGFBP2 by ECH1 expression — UCEC

Explore this box plot interactively →