ECEL1

Across TCGA patient cohorts, ECEL1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECEL1-associated genes across cancer lineages are Notch1, Src_pY416, and Cyclin-B1. Each is linked with ECEL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ECEL1-to-partner and partner-to-ECEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ECEL1-low versus ECEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECEL1→partner) and Y-score (partner→ECEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.157	+2.335	.005	.018	3	3
UCEC	Src_pY416 →	-0.259	-2.401	.007	.003	3	3
UCEC	Cyclin-B1 →	+0.611	+2.999	.006	.035	3	3
LUAD	P-Cadherin →	+0.251	+2.824	.040	.036	3	2
UCEC	GAPDH →	+0.453	+1.906	.035	.016	3	2
UCEC	INPP4B →	-0.264	-2.700	.042	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Notch1 by ECEL1 expression — UCEC

Explore this box plot interactively →