ECE1

Across TCGA pan-cancer cohorts, ECE1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ECE1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ECE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ECE1 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and PDAC are the cancer types where ECE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.524	0.847	.019	25	view →
LSCC	OS	Quartile	II,III,IV	0.798	1.000	.020	5	view →
PDAC	OS	Median	III,IV	0.431	0.743	.031	5	view →
GBM	DFS	Tertile	All	0.236	0.459	.017	4	view →
LUAD	OS	Tertile	All	0.736	0.962	.024	3	view →
UCEC	DFS	Tertile	All	0.844	0.955	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ECE1–CCRCC (DFS)

Open the CCRCC breakdown →