ECD

Across TCGA pan-cancer cohorts, ECD mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ECD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ECD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ECD is over-expressed in tumor.

CCRCC, PDAC, and LUAD are the cancer types where ECD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ECD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.119	<.001	8	view →
PDAC	All	All	+0.329	<.001	4	view →
LUAD	All	III,IV	+0.180	.029	2	view →
LSCC	All	All	+0.086	.009	2	view →
HNSC	Female	IV	+0.310	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ECD–CCRCC

Open the CCRCC breakdown →