EBP

Across TCGA patient cohorts, EBP mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EBP-associated genes across cancer lineages are PDCD4, Rad50, and c-Met_pY1235. Each is linked with EBP in more than 1 cancer types. Because this analysis shows association rather than direction, both EBP-to-partner and partner-to-EBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by EBP-low versus EBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBP→partner) and Y-score (partner→EBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.504	-3.160	.026	.019	3	1
UCEC	Rad50 →	-0.239	-2.459	.041	.020	3	1
UCEC	c-Met_pY1235 →	+0.090	+2.179	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PDCD4 by EBP expression — UCEC

Explore this box plot interactively →