EBI3

Across TCGA pan-cancer cohorts, EBI3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of EBI3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EBI3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EBI3 is over-expressed in tumor, although a few such as COAD and CHOL show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where EBI3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EBI3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.280	<.001	12	view →
THCA	All	IV	+3.157	<.001	10	view →
COAD	Male	All	−0.962	<.001	10	view →
KIRP	Female	All	+1.894	<.001	7	view →
STAD	Female	All	+1.602	.029	4	view →
ESCA	All	II,III,IV	+1.435	.017	4	view →
LUAD	Male	III,IV	+0.904	.001	4	view →
CHOL	All	II,III,IV	−2.045	.028	2	view →
HNSC	All	All	+0.426	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

EBI3–KIRC

Open the KIRC breakdown →