EBF4

Across TCGA patient cohorts, EBF4 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EBF4-associated genes across cancer lineages are SRIP1, IGHD5-5, and OR2AI1P. Each is linked with EBF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EBF4-to-partner and partner-to-EBF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRIP1 grouped by EBF4-low versus EBF4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF4→partner) and Y-score (partner→EBF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRIP1 →	+0.191	+6.639	<.001	.001	3	2
UCEC	IGHD5-5 →	+0.215	+4.896	<.001	.001	3	2
CESC	OR2AI1P →	+0.032	+4.669	<.001	.007	3	1
CESC	TUBB8P3 →	+0.039	+4.812	<.001	.006	3	1
CESC	MTND2P31 →	+0.162	+4.551	<.001	.004	3	1
CESC	MIR2467 →	+0.677	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

SRIP1 by EBF4 expression — BRCA

Explore this box plot interactively →