EBF4

Across TCGA cell cohorts, EBF4 mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EBF4-associated genes across cancer lineages are FGF3, C1orf141, and IQCF2. Each is linked with EBF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EBF4-to-partner and partner-to-EBF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF3 grouped by EBF4-low versus EBF4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF4→partner) and Y-score (partner→EBF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FGF3 →	+0.053	+4.981	<.001	.008	3	1
CNS	C1orf141 →	+0.016	+5.321	<.001	.005	3	1
OVARY	IQCF2 →	+0.052	+5.196	<.001	.005	3	1
SKIN	OR4S2 →	+0.026	+4.437	<.001	.004	3	1
SKIN	TMCO2 →	+0.069	+4.196	<.001	.002	3	1
SKIN	SLC22A6 →	+0.004	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

FGF3 by EBF4 expression — CNS

Explore this box plot interactively →