EBF3

Across TCGA patient cohorts, EBF3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EBF3-associated genes across cancer lineages are eIF4E, ERK2, and p70-S6K_pT389. Each is linked with EBF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EBF3-to-partner and partner-to-EBF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EBF3-low versus EBF3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF3→partner) and Y-score (partner→EBF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.179	+2.000	.024	.031	3	3
UCEC	ERK2 →	+0.142	+3.321	.017	.009	3	3
SKCM	p70-S6K_pT389 →	-0.147	-2.000	.046	.031	3	2
SKCM	PCNA →	+0.226	+2.000	.008	.031	2	3
SKCM	cIAP →	+0.210	+2.700	.001	.006	3	2
UCEC	MEK1 →	+0.291	+1.925	.010	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by EBF3 expression — SKCM

Explore this box plot interactively →