EBF3

Across TCGA cell cohorts, EBF3 mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EBF3-associated genes across cancer lineages are ETDB, SSX7, and GC. Each is linked with EBF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EBF3-to-partner and partner-to-EBF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETDB grouped by EBF3-low versus EBF3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF3→partner) and Y-score (partner→EBF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ETDB →	+0.101	+3.736	.001	.007	3	2
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
CNS	GC →	+0.034	+4.584	.003	.001	3	1
CNS	OR7E24 →	+0.008	+4.772	<.001	.002	3	1
LUNG_SCLC	GJA8 →	+0.136	+3.817	<.001	.004	3	1
LUNG_SCLC	PSG8 →	+0.133	+3.898	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

ETDB by EBF3 expression — LUNG_SCLC

Explore this box plot interactively →