EBF1

Across TCGA patient cohorts, EBF1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EBF1-associated genes across cancer lineages are MEK1, Shc_pY317, and Cyclin-B1. Each is linked with EBF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EBF1-to-partner and partner-to-EBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by EBF1-low versus EBF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF1→partner) and Y-score (partner→EBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.351	+2.115	.002	<.001	3	2
UCEC	Shc_pY317 →	-0.177	-1.836	<.001	.001	3	2
COAD	Cyclin-B1 →	+0.563	+3.016	.028	.018	3	2
UCEC	eEF2 →	+0.231	+2.000	.040	.029	3	2
UCEC	ATM →	-0.592	-2.115	<.001	<.001	3	2
UCEC	C-Raf_pS338 →	-0.065	-1.365	.011	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

MEK1 by EBF1 expression — UCEC

Explore this box plot interactively →