EARS2

Across TCGA patient cohorts, EARS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,902 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EARS2-associated proteins across cancer lineages are PARN, KDM3B, and DCTPP1. Each is linked with EARS2 in more than 7 cancer types. Because this analysis shows association rather than direction, both EARS2-to-partner and partner-to-EARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EARS2 versus PARN in OV, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EARS2→partner) and Y-score (partner→EARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PARN →	+0.330	+0.589	<.001	<.001	3	8
OV	KDM3B →	+0.265	+0.499	.003	<.001	3	7
LSCC	DCTPP1 →	+0.591	+0.368	<.001	<.001	3	7
LSCC	POLR3E →	+0.325	+0.504	<.001	<.001	3	7
BRCA	MRTFB →	+0.605	+0.666	<.001	<.001	3	6
OV	POLR3D →	+0.280	+0.492	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,902 associations by consensus.

EARS2 vs PARN — OV

Explore this scatter interactively →