EARS2

Across TCGA patient cohorts, EARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,416 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible EARS2-associated genes across cancer lineages are TUFM, ITGB1, and SRGAP2C. Each is linked with EARS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both EARS2-to-partner and partner-to-EARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EARS2 versus TUFM in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EARS2→partner) and Y-score (partner→EARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TUFM →	+0.444	+0.273	.001	.005	3	5
CCRCC	ITGB1 →	-0.525	-0.395	<.001	<.001	3	4
LUAD	SRGAP2C →	-0.372	-0.273	.001	.006	3	4
OV	DCTPP1 →	+0.768	+0.451	<.001	<.001	3	4
OV	ZNF530 →	-0.564	-0.297	<.001	.003	3	4
OV	NRP1 →	-0.789	-0.397	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,416 associations by consensus.

EARS2 vs TUFM — BRCA

Explore this scatter interactively →