EAF1

Across TCGA pan-cancer cohorts, EAF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EAF1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EAF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EAF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where EAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.297	0.606	.008	22	view →
HNSC	DFS	Tertile	All	1.000	0.903	.015	8	view →
LUAD	DFS	Quartile	All	0.844	0.955	.011	5	view →
GBM	OS	Median	All	0.657	0.859	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EAF1–PDAC (DFS)

Open the PDAC breakdown →