EAF1

Across TCGA patient cohorts, EAF1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EAF1-associated genes across cancer lineages are ATM, mTOR_pS2448, and eIF4E. Each is linked with EAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EAF1-to-partner and partner-to-EAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EAF1-low versus EAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EAF1→partner) and Y-score (partner→EAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.350	-2.986	.044	.035	3	3
UCEC	mTOR_pS2448 →	-0.147	-3.156	.010	.018	3	2
UCEC	eIF4E →	+0.237	+3.183	.003	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.170	-2.492	<.001	.001	3	1
UCEC	ACC1 →	+0.294	+2.335	.035	.018	3	1
UCEC	ACVRL1 →	-0.105	-2.446	.044	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ATM by EAF1 expression — UCEC

Explore this box plot interactively →