E4F1

Across TCGA patient cohorts, E4F1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,847 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E4F1-associated proteins across cancer lineages are STAG1, ING4, and CBX8. Each is linked with E4F1 in more than 3 cancer types. Because this analysis shows association rather than direction, both E4F1-to-partner and partner-to-E4F1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E4F1 versus STAG1 in GBM, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E4F1→partner) and Y-score (partner→E4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAG1 →	+0.324	+0.408	<.001	<.001	3	4
BRCA	ING4 →	+0.425	+0.837	<.001	<.001	3	4
GBM	CBX8 →	+0.406	+0.246	.002	.004	3	4
BRCA	CREBBP →	+0.344	+0.816	<.001	<.001	3	4
LSCC	EHMT1 →	+0.342	+0.370	<.001	<.001	3	4
BRCA	FLYWCH2_S21 →	+0.492	+0.797	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,847 associations by consensus.

E4F1 vs STAG1 — GBM

Explore this scatter interactively →