E4F1

Across TCGA patient cohorts, E4F1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,603 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E4F1-associated genes across cancer lineages are TRIM29, PEA15, and ZNF131. Each is linked with E4F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E4F1-to-partner and partner-to-E4F1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E4F1 versus TRIM29 in UCEC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E4F1→partner) and Y-score (partner→E4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM29 →	-1.406	-0.246	<.001	<.001	3	2
UCEC	PEA15 →	+0.603	+0.223	.001	<.001	3	2
LSCC	ZNF131 →	+0.391	+0.126	.003	.007	3	2
UCEC	CCR8 →	+0.848	+0.163	.004	.003	3	2
UCEC	KRT16 →	-2.406	-0.253	<.001	<.001	3	2
LSCC	CAPN8 →	-1.062	-0.151	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,603 associations by consensus.

E4F1 vs TRIM29 — UCEC

Explore this scatter interactively →