E4F1

Across TCGA patient cohorts, E4F1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E4F1-associated genes across cancer lineages are eIF4E, ERK2, and INPP4B. Each is linked with E4F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E4F1-to-partner and partner-to-E4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by E4F1-low versus E4F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E4F1→partner) and Y-score (partner→E4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+1.906	.018	.016	3	2
UCEC	ERK2 →	+0.244	+2.000	.001	.029	3	2
COAD	INPP4B →	-0.410	-2.313	.014	.035	3	2
UCEC	MEK1 →	+0.440	+3.087	.002	<.001	3	2
UCEC	PCNA →	+0.298	+2.807	<.001	.003	3	2
COAD	ATM →	-0.765	-3.169	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by E4F1 expression — UCEC

Explore this box plot interactively →