E4F1

Across TCGA cell cohorts, E4F1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,489 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E4F1-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Pre-mRNA catabolic process, and Double-strand break repair via single-strand annealing. Each is linked with E4F1 in more than 16 cancer types. Because this analysis shows association rather than direction, both E4F1-to-partner and partner-to-E4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by E4F1-low versus E4F1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E4F1→partner) and Y-score (partner→E4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.170	+1.361	<.001	<.001	3	17
BONE	Pre-mRNA catabolic process →	+0.199	+0.993	<.001	<.001	3	17
BONE	Double-strand break repair via single-strand annealing →	+0.084	+0.927	<.001	<.001	3	16
STOMACH	Calcium-independent cell-matrix adhesion →	+0.246	+0.684	<.001	.001	3	16
BONE	DNA double-strand break processing involved in repair via single-strand annealing →	+0.084	+0.927	<.001	<.001	3	16
URINARY_TRACT	CAMP/PKA signal transduction →	+0.195	+0.927	<.001	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,489 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by E4F1 expression — OESOPHAGUS

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